Bio-hacking a plasmid based DNA vaccine


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OP-Vent

https://op-vent.stanford.edu/ A different take: without an ambu bag. Claims: A mechanical ventilator design developed by Dally can be assembled quickly, using off-the-shelf parts with a total cost of around $400 — making it an accessible and affordable alternative to traditional, dedicated ventilators, which can cost $20,000 or more. Includes just two central components — a solenoid valve and a microcontroller. The design is called the OP-Vent , and in the video below you can see how bare-bones it is in terms of hardware compared to existing alternatives, including some of the other more complex emergency-use ventilator designs developed in response to COVID-19. Has been developed using input from mechanical engineers and doctors, including Dr. Andrew Moore, a chief resident at Stanford University and Dr. Bryant Lin, a medical devices expert and company co-founder. Can be assembled in as little as five minutes, and is small enough to fit in a Pelican case for easy transpor...
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Breathless Journalism

from https://old.reddit.com/r/pics/comments/foo7qm/italian_guy_designed_a_3d_printable_valve_to_turn/ [–] Vandimal88 184 points 14 hours ago   It looks like it would essentially work as non-invasive positive airway pressure similar to CPAP or BIPAP. That still uses positive pressure to force air into the lungs but without a tube that goes down the trachea past the vocal cords. There are many limitations on this kind of ventilation compared to intubation. With intubated patients you can control parameters such as positive end expiratory pressure (PEEP) which helps stent open the alveoli when they fill with fluid (acute respiratory distress syndrome) which is a common complication from COVID-19. You can’t reliably control all of these parameters with non-invasive positive airway pressure because it relies on the patient to be able to take their own breaths. They can tire out or if their mental status deteriorates and they are not able to maintain their airway ...
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Ventilator induced injury

From https://en.wikipedia.org/wiki/Mechanical_ventilation Risk Mechanical ventilation is often a life-saving intervention, but carries potential complications including pneumothorax , airway injury, alveolar damage, ventilator-associated pneumonia , and ventilator-associated tracheobronchitis . [4] [5] Other complications include diaphragm atrophy, decreased cardiac output, and oxygen toxicity. One of the primary complications that presents in patients mechanically ventilated is acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). ALI/ARDS are recognized as significant contributors to patient morbidity and mortality. [6] In many healthcare systems, prolonged ventilation as part of intensive care is a limited resource (in that there are only so many patients that can receive care at any given moment). It is used to support a single failing organ system (the lungs) and cannot reverse any underlying disease process (such as terminal cancer). For this reason...
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